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Sion considerably rescued Purkinje cell density in posterior (lobules VIII-X) but not anterior cerebellar lobules (Fig 4B and 4CJ). Purkinje cell rescue in posterior lobules was confirmed by immunofluorescence staining for calbindin, a marker of Purkinje cells (Fig 4G versus 4I). This rescue was linked with the expression of HA-tagged HSPB1 transgene (Fig 4H versus 4J). Transgene expression was al


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